Guzy, Serge Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/ Pharmacodynamic (PK/PD) Data
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van Eijkeren, J.C.H. (1), M.J. Zeilmaker (1), C.A. Kan (2), L.A.P. Hoogendoorn (3) and W.A. Traag (3) Model building and model parameter identification for transfer of dioxin TEQs from feed to eggs.
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Thomas, F.(1), S Séronie-Vivien(1), F Bouissou(2), M Tafani(2), JP Delord(1), L Gladieff(1), E Chatelut(1) Cystatin C as a new covariate to predict the renal elimination of drugs
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Grasela, Thaddeus(1), Jill Fiedler-Kelly(1), Cynthia Walawander(1), Charles W. Dement(2) Challenges in the Transition to Model-Based Development
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Zandvliet, Anthe S. (1), Wandena S. Siegel-Lakhai (1), Jan H.M. Schellens (2,3), William Copalu (4), Gerard Milano (5), Jos H. Beijnen (1,3), Alwin D.R. Huitema (1) Semi-mechanistic PK/PD model of indisulam in combination with capecitabine: a time-dependent pharmacokinetic interaction contributes to excessive hematological toxicity
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Roy, A. and M. Pfister Optimizing Dose Selection With Respect to Multiple Safety/Efficacy Endpoints Using Clinical Utility Concepts
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Hénin, Emilie(1), Klaas P. Zuideveld (2), Céline Dartois (1), Brigitte Tranchand (1,3), Gilles Freyer (1,4), Pascal Girard (1,5) A KPD Model for ordered categorical data: application to toxicity score in colorectal cancer patients treated with capecitabine
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Elsherbiny, D.(1), S. Asimus(2), M.O. Karlsson(1), M. Ashton(2), U. S. H. Simonsson(1) Modeling of the induction of CYP2B6 and CYP2C19 by artemisinin antimalarials
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Samson, Adeline (1), Marc Lavielle (2) and France Mentré (1) The SAEM algorithm for non-linear mixed models with left-censored data and differential systems: application to the joint modeling of HIV viral load and CD4 dynamics under treatment
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Ribbing, J. (1), J. Nyberg (1), O. Caster (1), E.N. Jonsson (1,2) The LASSO - A Novel Method for Predictive Covariate Model Building in Nonlinear Mixed Effects Models
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Savic, Radojka M. , Maria C. Kjellsson, Mats O. Karlsson Evaluation of the nonparametric estimation method in NONMEM VI beta
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Mondick, John T.(1), Leonid Gibiansky (2), Marc R. Gastonguay (2), Gareth J. Veal (3), Jeffrey S. Barrett (1) Acknowledging Parameter Uncertainty in the Simulation-Based Design of an Actinomycin-D Pharmacokinetic Study in Pediatric Patients with Wilms’ Tumor or Rhabdomyosarcoma
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Kowalski, Kenneth G., Stephen Olson, Ann Remmers A Modeling and Simulation Case Study: Impact on an Early Clinical Development Program
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Vicini, Paolo The Population Approach Identity Crisis: The Search For Innovation In Modeling And Simulation
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Renard, D.(1b), J. Witcher (1a), Y. Nie (2), F. Vandenhende (1b), A. Kumar (3), J. Miller (1a), J. Tauscher (1a), Y. Zhou (3), D. Wong (3) Bayesian Hierarchical Modeling of Receptor Occupancy in PET Trials
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Gibiansky, Ekaterina (1), Leonid Gibiansky (2) Model-Based Drug Development: Optimization of AQUAVAN® Injection Dosing for Minimal-to-Moderate Sedation
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Viberg, Anders (1), Otto Cars (2), Mats O. Karlsson (1) and Siv Jönsson (3) Individualization of Cefuroxime Dosage using Pharmacodynamic targets, MIC distributions and Minimization of a Risk Function
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Woltosz, Walter S. and Michael B. Bolger Simulation of the Nonlinear PK of Gabapentin and Midazolam in Adult and Pediatric Populations
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Edginton, A.N.(1), S. Willmann (1), Sevestre, M (2), Kirchheiner, J (3) Determining the effect of CYP2C9 genotypes on diclofenac metabolism using individualized coupled physiology-based pharmacokinetic modeling
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Dartois, C (1)(4), K Brendel (2)(4), E Comets (2), C Laveille (3), C Laffont (4), B Tranchand (1)(5), F Mentré (2), A Lemenuel-Diot (4), and P Girard (1)(6). How is model building reported for population PK-PD? An exhaustive survey of the literature between 2002 and 2004
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Hooker, Andrew, Christine E. Staatz and Mats O. Karlsson. Conditional weighted residuals, an improved model diagnostic for the FO/FOCE methods.
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Brendel, Karl(1,3), Céline Dartois(2,3), Emmanuelle Comets(1), Christian Laveille(4), Annabelle Lemmenuel-Diot(3), Brigitte Tranchand(2,6), Pascal Girard(2,5), Céline Laffont(3), France Mentré(1) Are population PK/PD models adequately evaluated? An exhaustive survey of the literature between 2002 and 2004
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Hutmacher, Matthew M , Anand Vidyashankar, and Debu Mukherjee Model Selection Using the Minimum Hellinger Distance Criterion (MHDC) with an Introduction to Minimum Hellinger Distance Estimation (MHDE)
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Willmann, Stefan, Andrea N. Edginton, Walter Schmitt, Marcus Kleine-Besten, and Jennifer B. Dressman Simulating Oral Absorption with PK-Sim®: Methodology and Application Examples
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Karlsson, Mats O. and Radojka Savić Overview of oral absorption models and modelling issues
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Rostami-Hodjegan, A. Complications in assessing the hepatic first-pass component of bioavailability
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